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Conferences

Where Great Minds Meet

International

  1. XY Zhu, YK Soh, MX Wan, JKS Pang, C Tian, BS Soh, ECY Chan. Investigation of the role of human CYP2J2*7 in proarrhythmia. ASPET 2024 Annual Meeting, May 16-19, Arlington, Virginia, USA. Travel award and the Predoctoral Poster Award (2nd Prize in Cardiovascular Pharmacology)

  2. AYF Tan, KB Schneck, LS Tham, ECY Chan. Using Phase 1 Glycemic Data in the Evaluation of Two Semi-mechanistic PK/PD Models for Predicting Long-term HbA1c in Type 2 Diabetes. 5th Asian Pharmacometrics Network Symposium 2023, November 29-30, Japan.

  3. Z Wang, CY Soo, EML Goh, HY Moy, ECY Chan. Metabolism of (-)-∆9-Tetrahydrocannabinol (THC) in Chicken and Potential Exposure of THC and Its Metabolites to Humans. ASPET 2023 Annual Meeting, May 18-21, St. Louis, MO, USA. Journal of Pharmacology and Experimental Therapeutics 2023, 385 (S3) 176. 3rd Place prize in DMD Division Postdoctoral Poster Competition

  4. AYF Tan, KG Oon, WM Siar, ECY Chan. Development of pharmacokinetic/pharmacodynamic (PKPD) database of dapagliflozin for the treatment of type 2 diabetes mellitus (T2DM). 4th Asian Pharmacometrics Network Symposium 2022, November 9-10, Malaysia.

  5. LWT Tang, W Wei, JRK Verma, H Fan, ECY Chan. Flexibility of the F-F’ loop, crucial for substrate access to the CYP3A4 active site, is reduced upon allosteric inhibition: A novel mechanism to rationalize probe substrate dependencies in Ki. 24th International Symposium on Microsomes and Drug Oxidations (MDO) and 13th International Meeting of the International Society for the Study of Xenobiotics (ISSX) 2022, September 11-14, Seattle, Washington, United States. Poster award finalist

  6. LWT Tang, G Wu, ECY Chan. Characterization of infigratinib as a reversible inhibitor and mechanism-based inactivator of CYP2J2. 22nd International Conference on Cytochrome P450 2022, July 17-21, Washington, D.C. United States. Klaus Ruckpaul Poster award

  7. LWT Tang, W Wei, RK Verma, SK Koh, L Zhou, H Fan, ECY Chan. Idirect and sequential Bioactivation of pemigatinib to a reactive iminium ion intermediate culminates in mechanism-based inactivation of Cytochrome P450 3A. Experimental Biology 2022, April 2-5, Philadelphia, Pennsylvania, United States. FASEB Journal 2022, (36) Supp. S1 539.2. DOI:10.1096/fasebj.2022.36.S1.0R684 Travel Grant Award

  8. EJY Cheong, TJ Yap, EZB Cheong, HT Tu, R Mahendran, E Chiong, K Esuvaranathan, CLL Chai, ECY Chan. Iterative development and verification of a middle-out PBPK model for Abiraterone. 12th International ISSX Meeting 2019, July 28-31, Portland, Oregon, United States. Supp. 14 P211

  9. JWH Leow, ABH Lim, RK Verma, H Fan, ECY Chan. Predicting risk of cardiac arrhythmias based on inhibitory potencies (Ki) against CYP2J2-mediated arachidonic acid metabolism. 12th International ISSX Meeting 2019, July 28-31, Portland, Oregon, United States. Supp. 14 P102

  10. SH Lee, JY Low, DYQ Kioh, C Wilder-Smith, ECY Chan. Systemic exposure of orally ingested fructose is similar between fructose-tolerant and fructose-intolerant Functional Gastrointestinal Disorder (FGID) patients. Experimental Biology 2019, April 6-9, Orlando, Florida, United States. FASEB Journal 2019, (33) Supp. 1 587.4. DOI: 10.1096/fasebj.2019.33.1_supplement.587.4

  11. JCY Chan, SPF Tan, ECY Chan. Quantitative proteomics-based bottom up PBK modeling: A case study of 3 statins. Experimental Biology 2019, April 6-9, Orlando, Florida, United States. FASEB Journal 2019, (33) Supp. 1 814.5. DOI: 10.1096/fasebj.2019.33.1_supplement.814.5

  12. JWH Leow, ECY Chan. Human CYP2J2 inhibition by azole antifungals. 12th Globalization of Pharmaceutics Education Network Conference (GPEN2018), September 26-29, National University of Singapore, Singapore.

  13. EJY Cheong, RWY Neo, PC Nair, TT Ho, F Lin, R Mahendran, E Chiong, K Esuvaranthan, H Fan, CLL Chai, JO Miners, ECY Chan. Slow and tight binding inhibition kinetics of CYP17A1 by Abiraterone and its active metabolite. 12th Globalization of Pharmaceutics Education Network Conference (GPEN2018), September 26-29, National University of Singapore, Singapore.

  14. SH Lee, K Esuvaranathan, TP Thamboo, E Chiong, BJ Chionh, YX Lim, SN Choo, LNM Raman, R Mahendran, ECY Chan. Tryptophan metabolism and IDO/TDO expression in bladder cancer: A case-control study in Singapore. 12th Globalization of Pharmaceutics Education Network Conference (GPEN2018), September 26-29, National University of Singapore, Singapore.

  15. EJY Cheong, RWY Neo, TT Ho, F Lin, R Mahendran, E Chiong, K Esuvaranathan, H Fan, CLL Chai, ECY Chan. Slow and Tight Binding Inhibition Kinetics of CYP17A1 by Abiraterone and Its Active Metabolite. 6th Asia Pacific ISSX Meeting 2018, May 11-14, Zhejiang University, Hangzhou, China. First Prize Predoctoral Poster Award cum Podium Presentation

  16. A Karkhanis, A Mehta, W Shim and ECY Chan. CYP2J2 Inhibition: The arcane mechanism of dronedorane-induced proarryhmia. Experimental Biology 2018, April 21-24, San Diego, California, United States. FASEB Journal 2018, (32) Supp. 1 833.9.

  17. SH Lee, K Esuvaranathan, TP Thamboo, E Chiong, BJ Chionh, YX Lim, SN Choo, LNM Raman, R Mahendran and ECY CHAN. Tryptophan metabolism and IDO/TDO expression in bladder cancer: A case-control study in Singapore. Experimental Biology 2018, April 21-24, San Diego, California, United States. FASEB Journal 2018, (32) Supp. 1 566.13.

  18. A Karkhanis, NDT Tram and ECY Chan. Perturbation of arachidonic acid metabolism by antiarrhythmic drugs: Implications in cardiac safety? 2nd Conference of the Society for the Study of Xenobiotics (SSX) 2017, October 25-29, Indian Institute of Science, Bangalore, India. Invited Podium Presentation cum First Prize Award (Postgraduate)

  19. A Karkhanis, NDT Tram and ECY Chan. Perturbation of arachidonic acid metabolism by antiarrhythmic drugs: Implications in cardiac safety? AAPS-NUS 12th PharmSci@Asia Symposium, July 4-5, Chinese University of Hong Kong, China. Best Poster Presentation Award 

  20. EJY Cheong, JJN Goh, Y Hong,  ECY Chan. Co-administration of amiodarone and rivaroxaban: A PBPK guided approach for prospective dose adjustments in the presence of complex drug-drug interactions. 14th European ISSX Meeting 2017, June 26-29, Cologne, Germany. Supp. 12 A2 Invited Podium Presentation cum Predoctoral Poster Award Finalist 

  21. SH Lee, V Limviphuvadh, M Maurer-Stroh, HK Chin, SK Ng,  ECY Chan. Unraveling the interindividual variation of urinary hippurate: in silico investigation of single nucleotide polymorphisms along the phenylproionate-hippurate axis. 14th European ISSX Meeting 2017, June 26-29, Cologne, Germany. Supp. 12 P77

  22. JCY Chan, F Lin, H Fan, ECY Chan. Electrophilic reactivity of and human serum albumin conjugation by para-phenylenediamine and its oxidized products: In vitro and in silico evaluation. 14th European ISSX Meeting 2017, June 26-29, Cologne, Germany. Supp. 12 P88

  23. JCY Chan, DYQ Kioh, CSM Goh, J Common, ECY Chan. Estimation of intradermal fraction of abiotically oxidizable para-phenylenediamine using metabolically active keratinocytes. 14th European ISSX Meeting 2017, June 26-29, Cologne, Germany. Supp. 12 P89

  24. ECY Chan, JCY Chan. Proteo-metabolomics in elucidating mechanisms of acetaminophen toxicity. 11th International ISSX Meeting 2016, June 12-16, Busan, South Korea. Drug Metabolism and Pharmacokinetics 2017, (32) S12-S13 Suppl 1.

  25. JCY Chan, DYQ Kioh, GC Yap, BW Lee, ECY Chan. Targeted LC/MS-based quantitative profiling of 15 gut microbiome-derived short-chain fatty acids in infant and adult stool. 11th International ISSX Meeting 2016, June 12-16, Busan, South Korea. Drug Metabolism and Pharmacokinetics 2017, (32) S62, Supp. 1.

  26. A Karkhanis, JWH Leow, YZ Khow, TY Ng, WW Teng, ECY Chan. Dronedarone inhibits CYP2J3 activity in H9c2 cardiomyocytes without mitochondrial toxicity. 11th International ISSX Meeting 2016, June 12-16, Busan, South Korea. Drug Metabolism and Pharmacokinetics 2017, (32) S72, Supp. 1.

  27. A Karkhanis, HY Lam, G Venkatesan, CLL Chai, L Zhou, Y Hong, P Kojodjojo, ECY Chan. Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites. Experimental Biology Meeting 2016, April 2-6, San Diego, USA.

  28. JCY Chan, ACK Soh, SK Koh, L Zhou, ECY Chan. Protein Glutathionylation: A New Dimension of Covalent Binding in Acetaminophen Toxicity. 20th North American Regional ISSX Meeting, October 18-22, Orlando, Florida, USA. Drug Metabolism Reviews 2016, (48) 116-117, Suppl 1.

  29. JCY Chan, PXL Teng, WJ Ng, PR Lim, ZT Su, KP Kumar, E Browne, PS Ong, ECY Chan. Combinatorial Lapatinib and Endoxifen Exhibits Pharmacodynamic and Pharmacokinetic Synergism in Tamoxifen-Resistant Breast Cancer. 20th North American Regional ISSX Meeting, October 18-22, Orlando, Florida, USA. Drug Metabolism Reviews 2016, (48) 21-22, Suppl 1. Third Prize Predoctoral Poster Award

  30. A Karkhanis, HY Lam, ECY Chan. Reversible inhibition and mechanism-based inactivation of human CYP2J2 by dronedarone and amiodarone. 13th European ISSX Meeting 2015, June 22-25, Glasgow, Scotland, United Kingdom.

  31. Y Hong, EJY Cheong, ECY Chan. Prediction of in vivo drug-drug interactions between dronedarone and rivaroxaban based on in vitro inhibition studies. 13th European ISSX Meeting 2015, June 22-25, Glasgow, Scotland, United Kingdom.

  32. LC Phua, CH Wilder-Smith, RK Wong, G Venkatesan, ECY Chan. In Combat Soldiers Resting Urinary Metabotypes Correlate With the Development of Gastrointestinal Symptoms During Stress. Digestive Disease Week 2015, May 16-19, Washington, DC, USA. Gastroenterology 2015, 148 (4), Suppl 1, S-21.

  33. LC Phua, CH Wilder-Smith, YM Tan, T Gopalakrishnan, RK Wong, X Li, ME Kan, J Lu, A Keshavarzian, ECY Chan. Combat-training stress mediates metabotypic changes associated with gastrointestinal symptoms and altered intestinal permeability. 22nd United European Gastroenterology Week 2014, October 18-22, Vienna, Austria. Gastroenterology2014, 146 (5), Suppl 1, S-533–S-534 Poster in the Spotlight

  34. LY Yip, SH Lee, YS Hong, JMX Chan, EY Koh, CC Aw, WS Chen, ER Browne, R Mahendran, YK Lee, ECY Chan. The gut microbiome: Implications in tacrine-induced transaminitis. 19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014, October 19-23, San Francisco, California, USA. Drug Metabolism Reviews 2015, (47) 36-37, Suppl 1. First Prize Predoctoral Poster Award cum Podium Presentation Faculty of Science Research News

  35. Y Hong, RH Yeo, ECY Chan. Inhibitory Effects of Dronedarone and its N-desbutyl metabolite on Human CYP3A4 and CYP3A5 Activities. 19th North American ISSX and 29th JSSX 2014, October 19-23, San Francisco, CA, USA. Drug Metabolism Reviews 2015 (47) 134-135, Suppl 1.

  36. JCY Chan, DYM Choo, ECY Chan. Impact of CYP3A5 genetic polymorphism on mechanism-based inactivation by lapatinib. 19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014, October 19-23, San Francisco, California, USA. Drug Metabolism Reviews(47) 173, Suppl 1. Invited Podium Presentation for “Drug-drug Interactions: Novel Mechanisms and Advances in Prediction” session Faculty of Science Research News

  37. JCY Chan, ACK Soh, SK Koh, L Zhou, ECY Chan. Protein glutathionylation: the hidden hand in acetaminophen toxicity. 19thNorth American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014, October 19-23, San Francisco, California, USA. Drug Metabolism Reviews 2015, (47) 36, Suppl 1. Second Prize Predoctoral Poster Award cum Podium Presentation

  38. JCY Chan, P Lim, PS Ong, ECY Chan. A metabolism-driven combinatorial approach to overcome ER/HER2 crosstalk in breast cancer. 19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014, October 19-23, San Francisco, California, USA. Drug Metabolism Reviews 2015, (47) 110, Suppl 1.

  39. LC Phua, YM Tan, RK Wong, X Li, CH Wilder-Smith, ECY Chan. Noninvasive urinary metabonomic diagnosis of inflammatory bowel disease using gas chromatography/mass spectrometry. Digestive Diseases Week 2014, June 3-6, Chicago, IL, USA. Gastroenterology 2014, 146 (5), Suppl 1, S-429

  40. LC Phua, CH Wilder-Smith, YM Tan, T Gopalakrishnan, RK Wong, X Li, ME Kan, J Lu, A Keshavarzian, ECY Chan. Combat-training stress mediates metabotypic changes associated with gastrointestinal symptoms and altered intestinal permeability. Digestive Diseases Week 2014, June 3-6, Chicago, IL, USA. Gastroenterology 2014, 146 (5), Suppl 1, S-533–S-534.

  41. LY Yip, HC Ku, CC Aw, WS Chen, ER Browne, R Mahendran, YK Lee, ECY Chan. Investigation of host-gut microbiome interaction in tacrine-dosed Lister-hooded rats through fecal metabolic profiling. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada. Drug Metabolism Reviews 2014, 147 (45), Suppl 1.

  42. LY Yip, JMX Chan, A Sampathkumar, R Mahendran, YK Lee, CC Aw, WS Chen, ER Browne, ECY Chan. Fecal microbiome profiling reveals association of β-glucuronidase producing bacteria with susceptibility to tacrine-induced hepatotoxicity. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada. Drug Metabolism Reviews 2014, 174 (45), Suppl 1.

  43. CY Chan, BL Nunn, DR Goodlett, SK Koh, L Zhou, ECY Chan. GluICAT: A novel liquid chromatography-mass spectrometry-based method for profiling protein glutathionylation. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada. Drug Metabolism Reviews 2014, 26-27 (45), Suppl 1. Predoctoral Poster Award Finalist

  44. HT Chng, YY Dan, SJ Lin, S Aparna, HK Ho, ECY Chan. Characterization of the drug disposition transcript profile of hepatocyte-like cells derived from human fetal liver multipotent progenitor cells and human amniotic epithelial cells. ADME & Predictive Toxicology 2013, 11-12 April, Barcelona, Spain. Poster Award

  45. Y Hong, YMF Chia, ECY Chan. Interaction of Dronedarone with Human CYP450 Enzymes: Metabolism and Inhibition. ADME & Predictive Toxicology 2013, April 11-12, Barcelona, Spain.

  46. YM Tan, HT Chng, P Chuah, SH Lam, ECY Chan. Zebrafish as an in vivo High-throughput Screening Model for CYP3A4 Induction. ADME & Predictive Toxicology 2013, April 11-12, Barcelona, Spain.

  47. P Bahety, YM Tan, Y Hong, ECY Chan and PLR Ee. Gas Chromatography/Time-Of-Flight Mass Spectrometry Metabotyping of Docosahexaenoic Acid-Treated Alzheimer’s Disease Cell Model. Globalization of Pharmaceutics Education Network Meeting (GPEN) 2012, November 28 – December 1, Melbourne, Australia. Biota and Teikoku Seiyaku Co. Ltd Housing Grant and Travel Grant Award

  48. HT Chng, RFS Lee, SH Lam, Z Gong, HK Ho and ECY Chan. Zebrafish: an in vivo high-throughput screening model for CYP3A4 induction and inhibition. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands. Predoctoral Poster Award Finalist

  49. LC Phua, PK Koh, PY Cheah, LY Yip, A Sampathkumar, YM Tan, HK Ho and ECY Chan. Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabotyping of lyophilized human feces. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.

  50. LY Yip,CC Aw, WS Chen, LS New, YM Tan, ER Browne, R Mahendran, YK Lee, ECY Chan. Exploring the Interaction of Host and Gut Microbiome in the Toxicokinetics of Tacrine. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.

  51. HT Chng, YY Dan, SJ Lin, HK Ho and ECY Chan. Basal gene expression of drug metabolizing enzymes, transporters and nuclear receptors in hepatocyte-like cells derived from human fetal liver multipotent progenitor cells. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.

  52. HT Chng, HK Ho, SH Lam and ECY Chan. Isolation of zebrafish (Danio rerio) liver microsomes: protocol and considerations. 9th International ISSX Meeting 2010, September 4-8, Istanbul. Drug Metabolism Reviews 42-S1 (2010) 190–191.

  53. ECY Chan, JW Oh, LS New and HK Ho. Investigating the molecular mechanism of lapatinib-induced liver toxicity”. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-S2 (2009) 89.

  54. LS New, CW Yap, LT Goh and ECY Chan. Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 53.

  55. X Ma and ECY Chan. Fluorescence-based screening of pharmaceutical reactive metabolites using glutathione immobilized 96-well microsomal assay. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 26-27. First Prize Postdoctoral Fellow Category

  56. S Saha, LS New, HK Ho, WK Chui and ECY Chan. Investigation of the role of thiazolidinedione of troglitazone in inducing hepatotoxicity in humans. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 26.

  57. KK Pasikanti, J Norasmara, R Mahendran, K Esuvaranathan, PC Ho and ECY Chan. Extracellular metabonomics of human non-tumorigenic and tumorigenic uroepithelial cells. Metabolomics 2008, September 2-6, Boston.

 

Local

  1. ​​JY Woon, JCY Chan, DYQ Kioh, BW Lee and ECY Chan. Global metabonomics of infant stool in childhood eczema. Pharmacy Research Awareness Symposium 2017, April 5, Singapore. First Prize Poster Award (PK Domain Category)

  2. RH Ho, JCY Chan, DYQ Kioh, BW Lee, H Fan and ECY Chan. Investigation of the Chemical Interactions Between Short Chain Fatty Acids and Human Histone Deacetylases. Pharmacy Research Awareness Symposium 2017, April 5, Singapore. Second Prize Poster Award (PK Domain Category)

  3. A Karkhanis, NDT Tram and ECY Chan. Perturbation of arachidonic acid metabolism by antiarrhythmic drugs: Implications in cardiac safety? Pharmacy Research Awareness Symposium 2017, March 28, Singapore. Best Poster Award (PhD Category)

  4. P Lim, JCY Chan, PS Ong and ECY Chan. A Combinatorial Approach to Targeting Molecularly Diverse Breast Cancer Phenotypes. 25th Singapore Pharmacy Congress 2015, September 12-13, Singapore. First Prize Poster Award (Pharmaceutical Sciences) 

  5. JCY Chan, WJ Ng, PXL Teng, ZT Su, KP Kumar, ER Browne, PR Lim, PS Ong and ECY Chan. Leveraging Pharmacodynamic and Pharmacokinetic Synergism in the Treatment of Breast Cancer. 10th PharmSci@ Asia Symposium 2015, April 09, Singapore. Best Poster Presentation Award

  6. A Karkhanis, HY Lam and ECY Chan. Inhibitory Effect of Dronedarone and Amiodarone on Human Cardiac CYP2J2. Yong Loo Lin School of Medicine 5th Annual Graduate Scientific Congress (AGSC) 2015, January 27, Singapore.

  7. LY Yip, HC Ku, CC Aw, WS Chen, ER Browne, R Mahendran, YK Lee and ECY Chan. Investigation of host-gut microbiome interaction in tacrine-dosed Lister-hooded rats through fecal metabolic profiling. Annual Pharmacy Research Symposium 2014, April 9, Singapore. First Prize for Postgraduate Abstract Presentation Contest (Pharmacokinetics/Toxicokinetics Category) 

  8. LY Yip, JMX Chan, A Sampathkumar, R Mahendran, YK Lee, CC Aw, WS Chen, ER Browne and ECY Chan. Fecal microbiome profiling reveals association of β-glucuronidase producing bacteria with susceptibility to tacrine-induced hepatotoxicity. Yong Loo Lin School of Medicine 4th Annual Graduate Scientific Congress (AGSC) 2014, March 11, Singapore. Best Poster Presentation Award

  9. LY Yip, CC Aw, WS Chen, LS New, YM Tan, ER Browne, R Mahendran, YK Lee and ECY Chan. Exploring the Interaction of Host and Gut Microbiome in the Toxicokinetics of Tacrine. Yong Loo Lin School of Medicine 3rd Annual Graduate Scientific Congress (AGSC) 2013, January 30, Singapore. Best Poster Presentation Award

  10. ECY Chan, LS New, KK Pasikanti, PW Goh, LY Yip, CW Goh, CC Aw and ER Browne. Toxicometabonomics phenotyping of tacrine-induced liver transaminitis.Singapore Society for Mass Spectrometry Conference 2011, September 22-23, Singapore. First Prize SSMS-Agilent 2011 Poster Award

  11. JW Oh, LS New, HK Ho and ECY Chan. Investigating the molecular mechanism of lapatinib-induced liver toxicity. Singapore Pharmacy Congress 2009, July 25-26, Singapore. First Prize Poster Category

 

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